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Faculty of MedicineThe Hackett Lab | Department of Anesthesiology, Pharmacology, & Therapeutics
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  • Our lab has access to services provided by the Lung Tissue Registry where we can obtain FFPE tissue samples for histology work and frozen samples for RNA, DNA and protein analysis. Read More

  • Our Goal

    To improve the health of patients living with asthma and chronic obstructive pulmonary disease (COPD), who are challenged every day with the simple task of breathing. Read More

  • Our Research

    We are focused on understanding the contribution of dysregulated epithelial repair to airway remodeling in asthma, developing microCT imaging methodology to understand small airways disease, and other imaging methodologies to understand multi-cellular tissues. Read More

Research Objectives:

The objectives of our research are to provide new approaches to predict risk, diagnose, and discover new treatments to improve the quality of life of asthma and COPD patients. Our central research objectives are:

  • Map the cellular, transcriptomic and extracellular matrix (ECM) microenvironment of early diseases lesions using single cell resolution technologies.
  • Develop clinical CT imaging tools for the early detection and monitoring of disease.
  • Identify therapeutic targets to improve asthma and COPD outcomes.

 

 

 

  • News
  • Recent Publications

 

 

 

Dr. Hackett talk, St. Paul’s Hospital Innovation Day, 2019.

 

 

 

 

Dr.’s Leila B. Mostaço-Guidolin and Emmanuel T. Osei presentation, ATS Journal Club, 2019.

 

 

 

 

 

Canadian Society of Hospital Pharmacists, 2018.

 

 

 

 

Dr. Hackett interview, Global TV, 2018.

 

  • DSecond harmonic generation imaging of collagen scaffolds within the alveolar ducts of healthy and emphysematous mouse lungs – PubMed (nih.gov)

 

  • Effects of cigarette smoking on SARS-CoV-2 receptor ACE2 expression in the respiratory epithelium † – PubMed (nih.gov)

 

  • Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) infections – PubMed (nih.gov)

 

  • Small airway loss in the physiologically ageing lung: a cross-sectional study in unused donor lungs – PubMed (nih.gov)

 

 

 

Funding Partners:

 

 

  

                       

 

 


 

 

     

 

 

        

 

 

The Hackett Lab | Department of Anesthesiology, Pharmacology, & Therapeutics
1081 Burrard Street
Rm 166
Vancouver, BC Canada V6Z 1Y6
Tel 604 806 8346
Fax 604 806 8351
Email info@hli.ubc.ca
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